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Celeb & Ent

Grey’s Anatomy Teases Jesse Williams’ Unexpected Return for Season 22

By Eric October 24, 2025

Jesse Williams is making a much-anticipated return to the iconic medical drama “Grey’s Anatomy,” reprising his role as Dr. Jackson Avery. Williams, who originally departed the show in 2021 after a significant 12-season run, left a lasting impact on both fans and the narrative of the series. His character, known for his charm, intelligence, and complex relationships, became a fan favorite over the years, particularly for his romantic entanglements with characters like April Kepner and his deep connections with fellow surgeons. This comeback is especially exciting for fans who have followed the series through its many twists and turns, as Williams’ return promises to reignite some of the show’s most beloved storylines.

The return of Williams comes at a pivotal moment for “Grey’s Anatomy,” which has seen a number of cast changes in recent years. With the departure of several key characters, including Ellen Pompeo’s Meredith Grey, the show has been navigating a new chapter in its long-running saga. Williams’ return not only brings back a familiar face but also injects fresh energy into the series, allowing for potential new dynamics and story arcs. His character’s rich backstory and connections to other characters at Grey Sloan Memorial present numerous opportunities for compelling storytelling. Fans are eager to see how Jackson’s experiences away from Seattle may have changed him and what role he will play in the evolving landscape of the hospital.

As “Grey’s Anatomy” continues to explore themes of love, loss, and resilience, Williams’ return is expected to resonate deeply with the audience. His character’s advocacy for social justice and personal growth have always been central to his storyline, and viewers are hopeful that his return will bring these themes back to the forefront. With the show still tackling relevant social issues and the complexities of modern medicine, Jackson Avery’s re-entry into the narrative is poised to enhance the show’s relevance and emotional depth. As fans await the details of his storyline, excitement is building for what this return will mean for both the character and the series as a whole.

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Jesse Williams is lacing up his scrub cap again. 
After his Grey’s Anatomy departure in 2021, the actor, who plays Dr. Jackson Avery, is set to make a rare return to Grey Sloan Memorial…

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Eric

Eric is a seasoned journalist covering Celeb & Ent news.

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