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A Different Type of Dementia Is Changing What’s Known About Cognitive Decline

By Eric December 6, 2025

In a poignant story highlighting the complexities of dementia diagnoses, Ray Hester’s journey took an unexpected turn when he was initially informed by doctors that he was in the early stages of Alzheimer’s disease. This diagnosis, which can often carry a heavy emotional burden, was later contradicted by a brain scan that revealed he actually had LATE (Limbic-predominant Age-related TDP-43 Encephalopathy) dementia, a less common form of dementia that affects the brain differently than Alzheimer’s. For Ray and his wife, Sandy, this revelation brought a sense of relief, as Sandy expressed, “There’s a certain amount of relief knowing that it’s not Alzheimer’s.” This statement underscores the psychological weight that comes with a diagnosis and the nuances that differentiate various forms of dementia.

LATE dementia is characterized by the accumulation of TDP-43 protein in the brain, which can lead to symptoms that may initially mimic Alzheimer’s, such as memory loss and cognitive decline. However, the progression and treatment options can differ significantly. For families facing dementia, understanding the specific type is crucial for navigating care and support. Ray’s experience serves as a reminder of the importance of thorough medical assessments, including brain imaging, to ensure accurate diagnoses. As the Hesters navigate this new chapter, their story sheds light on the broader implications of dementia awareness and the need for continued research and education on the various forms of this complex condition. Their journey emphasizes that while a diagnosis can be daunting, clarity can also bring a sense of hope and direction in managing the challenges ahead.

https://www.youtube.com/watch?v=IEy_xTPygN8

Doctors told Ray Hester he was in the beginning stages of Alzheimer’s, but a brain scan revealed instead he had LATE dementia. “There’s a certain amount of relief knowing that it’s not Alzheimer’s,” his wife, Sandy, said.

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