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Cervical cancer screening is about to change as cases rise among young women. Here’s what you should know.

By Eric December 4, 2025

Cervical cancer rates are on the rise, particularly among younger populations, largely due to a significant decline in screening practices following the COVID-19 pandemic. In response, the American Cancer Society (ACS) has introduced groundbreaking new guidelines that allow individuals to self-collect samples for HPV testing, the primary cause of cervical cancer. This marks a significant shift in cervical cancer prevention strategies, as it is the first major update since HPV testing was established as a preferred alternative to routine Pap smears in 2014. The new self-collection method is intended to simplify the screening process, making it more accessible and increasing participation rates, particularly among those who may have previously faced barriers to traditional screening methods.

The FDA has approved at-home testing kits that enable individuals to collect their own samples without the need for a pelvic exam, a change that is expected to enhance compliance with screening recommendations. Research indicates that self-collected samples yield results comparable to those taken by healthcare professionals, although some studies suggest they may be slightly less accurate. Nevertheless, this innovative approach is anticipated to address logistical challenges such as lack of insurance, long wait times, and discomfort associated with pelvic exams, which can deter individuals from seeking necessary screenings. Countries like Australia, where self-collection for HPV testing has been available since 2022, have already seen an increase in screening rates and a decline in cervical cancer cases, highlighting the potential effectiveness of this strategy.

The new guidelines recommend that cervical screening begin at age 25 for individuals of average risk, with HPV testing conducted every five years until age 65. If a self-collected sample returns negative, there is no need for an in-person Pap smear, streamlining the follow-up process. For abnormal results, further clinical evaluation may be necessary. This evolution in cervical cancer screening is part of a broader trend in healthcare aimed at making preventive care more accessible and effective. As Dr. Robert Smith of the ACS notes, these updated recommendations are expected to improve screening compliance and ultimately reduce the risk of cervical cancer, paving the way for a future where more individuals can take charge of their health with ease and confidence.

Cervical cancer is on the rise as screening has declined post-COVID. New guidelines aim to make it easier to test for HPV, the main cause of cervical cancer.
Keeproll/Getty Images
New testing options could make it easier to screen for the most common cause of cervical cancer.
An FDA-approved kit could allow for testing without a pap smear or pelvic exam.
The shift is among medical innovations aiming to curb the rising number of early-onset cancers.
People will soon be able to collect their own samples for cervical cancer screening, according to a major new update to the American Cancer Society’s screening guidelines.
It’s

the biggest shift in cervical cancer prevention since HPV testing became the preferred alternative to routine pap smears in 2014.
The new guidance allows patients to swab themselves to test for human papillomavirus (HPV), a sexually transmitted infection that is the primary
cause of cervical cancer
.
Cervical cancer rates are rising,
particularly in younger people, and screening has declined in recent years.
The hope is that this change — part of a broader trend in healthcare making
preventative care
simpler — will help to catch more cases by speeding up screening.
While the American Cancer Society (ACS) does not dictate federal screening rules, its guidelines are widely used by oncologists and health systems, often paving the way for formal policy changes.
New technology is helping cancer screening to “evolve,” said Dr. Robert Smith, senior author of the report and epidemiologist at the ACS.
“These updated recommendations will help to improve compliance with screening and reduce the risk of cervical cancer,” Smith said in a press release.
Screening is crucial for cancer prevention
Cervical cancer is among the most preventable — and treatable — types of cancer, thanks to HPV vaccinations and routine

screening. But rates of both have dropped in recent years, in part because the COVID-19 pandemic
disrupted access
to preventive care.
Until recently,
HPV screenings
meant booking an appointment with a clinician to collect a sample and do a pelvic exam.
That shifted in 2024, when the FDA green-lit testing for self-collected samples, initially in healthcare settings like primary care offices or mobile health clinics. This year, the agency went a step further, approving
at-home test
options with telehealth support.
Research suggests
the testing results for self-collected samples are on par with those collected by physicians when it comes to

screening for HPV. Some
data found
they’re slightly less accurate, which is why some doctors still prefer clinical samples when possible, according to the ACS.
Still, having an alternative to pelvic exams could increase HPV screening for people who may find it hard to get an appointment due lack of insurance, long wait lists, or logistical hurdles

like scheduling, transportation, or childcare.
Self-collection could also increase testing rates for people who may find a pelvic exam intimidating or uncomfortable, whether due to past trauma, medical anxiety, or simply personal preference.
In Australia, where self-collection for HPV became widely available in 2022, rates of cervical cancer have declined, and screening has increased among patients who had previously not been tested.
How it works
Kits for self-collecting samples for HPV testing are available now via prescription from your doctor (or in some cases, through a virtual appointment, depending on what state you live in).
Using the kit is fairly straightforward: you use a device that looks like a large Q-tip or tampon to swab the vagina for a sample, then send that sample

to a lab for screening. If the results are negative, you don’t need to get an
in-person Pap smear
.
For certain abnormal results, the next step may be a clinician-collected sample, or another HPV screening in one to three years, according to
NIH guidelines
.
The current guidelines recommend starting cervical screening at age 25 for people of average risk, and that HPV testing be done every five years through age 65. The full screening
guideline updates were published
in the American Cancer Society’s CA: A Cancer Journal for Clinicians.
Read the original article on
Business Insider

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