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Trump launches ‘Genesis Mission’ to supercharge US scientific AI innovation

By Eric November 25, 2025

On Monday, President Donald Trump signed a significant executive order aimed at enhancing the United States’ artificial intelligence (AI) initiatives, launching what is termed the “Genesis Mission.” This initiative is designed to accelerate the application of AI for scientific purposes by directing the Department of Energy (DOE) and the Office of Science and Technology Policy (OSTP) to collaborate with private companies. The focus will be on sharing federal data sets, advanced supercomputing capabilities, and the extensive resources of national laboratories. Secretary of Energy Chris Wright emphasized the need to pivot AI efforts from their current commercial focus—centered on language processing and consumer services—toward fostering advancements in scientific discovery and engineering.

The executive order also mandates the creation of an integrated platform by the DOE and national labs to streamline scientific discovery. This platform aims to connect AI capabilities with scientists, engineers, and technical staff, facilitating better use of the labs’ scientific instruments. This initiative follows the release of Trump’s AI policy framework in July, titled “Winning the Race: America’s AI Action Plan,” which outlines a strategy for the U.S. to lead in AI innovation and international diplomacy. During the recent U.S.-Saudi Investment Forum, Trump hinted at the broader ambitions of this initiative, stating that the U.S. aims to build the “largest, most powerful, most innovative AI ecosystem in the world.”

In addition to the Genesis Mission, the Trump administration is exploring further executive orders related to AI, including potential actions against states that implement their own AI regulations. Trump has voiced concerns that state-level regulations could hinder innovation, proposing a streamlined approval process that would prevent the need to navigate regulations across multiple states. This approach reflects a broader strategy to maintain the U.S.’s competitive edge in AI while ensuring that innovation is not stifled by fragmented regulatory landscapes. As the administration continues to develop its AI strategy, the implications for scientific research and technological advancement could be profound, potentially positioning the United States as a leader in the next wave of AI-driven discoveries.

https://www.youtube.com/watch?v=FQ92hV1R4TA

President
Donald Trump
signed an executive order Monday aimed at bolstering U.S. artificial intelligence (AI) initiatives as it unveiled its new “Genesis Mission” to accelerate AI use for scientific purposes. 
The “Genesis Mission” will direct the Department of Energy (DOE) and the Office of Science and Technology Policy (OSTP) and their national labs to work with private companies to share federal data sets,
advanced supercomputing capabilities
, and scientific facilities. 
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“The private sector has launched artificial intelligence at huge scale, but with a little bit different focus – on language, on business, on processes, on consumer services,” Secretary of Energy Chris Wright told reporters Monday. “What we’re doing here is just pivoting those efforts to focus on scientific discovery, engineering advancements. And to do that, you need the data sets that are contained across our national labs.” 
Additionally, the
executive order
instructs the Department of Energy and national labs to create an integrated platform aimed at expediting scientific discovery, in an attempt to connect AI capability with scientists, engineers, technical staff, and the labs’ scientific instruments, according to a White House official.
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Trump hinted an effort like this was in the works during the
U.S.-Saudi Investment Forum
Wednesday in Washington, where he said the U.S. would work “to build the largest, most powerful, most innovative AI ecosystem in the world.”
The effort comes after Trump issued an AI policy document called “Winning the Race: America’s AI Action Plan” in July. The document laid out a framework focused on accelerating AI innovation, ensuring the U.S. is the leader in international AI diplomacy and security, and using the private sector to help build up and operate AI infrastructure. 
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Meanwhile, the Trump administration is also currently considering other executive orders pertaining to AI, and more executive orders could be on the horizon. 
For example, Fox News Digital previously reported that the White House was gearing up an executive order instructing the Justice Department to sue states that adopt their own
laws regulating AI

Trump appeared to address the initiative at the U.S-Saudi Investment Forum as well, claiming that a series of AI regulations imposed at the state level would prove a “disaster.”
“And we are going to work it so that you’ll have a one approval process to not have to go through 50 states,” Trump said. 
Fox News’ Amanda Macias and Dennis Collins contributed to this report.

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