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Health

National patient safety alert – harm from incorrect recording of penicillin allergy as penicillamine allergy

By Eric November 21, 2025

In a significant development aimed at enhancing patient safety, NHS England’s National Patient Safety team has issued a joint alert in collaboration with the Royal Pharmaceutical Society, the Royal College of Physicians, and the Royal College of General Practitioners. This alert addresses a critical risk associated with the inadvertent recording of patients’ penicillin allergies as penicillamine allergies within electronic prescribing and medicines administration (EPMA) systems. Such misrecordings can lead to serious patient harm, as penicillin and penicillamine are distinct medications with different therapeutic uses and side effect profiles.

The alert emphasizes the importance of accurate allergy documentation in medical records, particularly in the context of antibiotic prescribing, where penicillin is commonly used. Misclassifying a patient’s allergy can result in the administration of inappropriate medications, increasing the risk of adverse drug reactions. For instance, patients with a documented penicillin allergy may be prescribed alternative antibiotics that are less effective or carry a higher risk of side effects. The alert calls on healthcare professionals to ensure meticulous attention to detail when entering allergy information into EPMA systems and to verify existing records during patient consultations. It also highlights the need for ongoing education and training for medical staff to prevent such critical errors, ultimately aiming to enhance patient safety and improve healthcare outcomes.

This initiative underscores the NHS’s commitment to patient safety and the need for collaborative efforts across medical disciplines to address potential risks associated with electronic health records. By raising awareness of this specific issue, the joint alert seeks to foster a culture of safety within healthcare settings, encouraging practitioners to be vigilant and proactive in their documentation practices. As healthcare technology continues to evolve, the importance of accurate and reliable data entry cannot be overstated, as it plays a vital role in ensuring that patients receive safe and effective care.

A joint National Patient Safety Alert has been issued by the NHS England National Patient Safety team, in collaboration with the Royal Pharmaceutical Society, Royal College of Physicians and Royal College of General Practitioners, about the risk of harm from inadvertently recording patients’ penicillin allergies as penicillamine allergies in electronic prescribing and medicines administration (EPMA) […]

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