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Personalised ‘living drug’ to offer “hope of cure” for aggressive leukaemia on NHS

By Eric December 7, 2025

In a significant advancement for cancer treatment, patients battling an aggressive form of leukaemia will soon have access to a groundbreaking immunotherapy on the NHS. The therapy, known as ‘obe-cel’ (also referred to as CAR T-cell therapy), has demonstrated remarkable efficacy in clinical trials, with over 75% of participants achieving remission. This innovative treatment involves extracting a patient’s immune cells, which are then genetically reprogrammed in a laboratory to specifically identify and attack cancerous cells. This personalized approach not only enhances the immune system’s ability to combat the disease but also represents a shift towards more tailored cancer therapies, offering new hope to those with limited treatment options.

The introduction of obe-cel to NHS treatment protocols marks a pivotal moment in the fight against leukaemia, particularly for patients with relapsed or refractory B-cell malignancies. The therapy has shown promising results in trials, where it effectively eradicated cancer cells in a significant number of participants. For instance, in a recent trial involving patients with aggressive forms of leukaemia, the therapy led to a notable reduction in cancer symptoms and improved overall survival rates. The NHS’s decision to adopt this treatment reflects a broader commitment to integrating cutting-edge medical innovations into standard care, ensuring that patients have access to the latest advancements in cancer therapy.

This development not only underscores the potential of immunotherapy in treating complex cancers but also highlights the importance of ongoing research and investment in medical science. As the NHS rolls out obe-cel, it opens the door for further exploration into similar therapies that could revolutionize cancer treatment in the future. The hope is that with continued advancements, more patients will benefit from personalized treatments that harness the power of their own immune systems, leading to better outcomes and a higher quality of life for those affected by this challenging disease.

Patients with an aggressive form of leukaemia will be able to receive a breakthrough immunotherapy on the NHS that saw over three quarters of patients go into remission in trials. The CAR T-cell therapy – known as ‘obe-cel’ – involves taking a patient’s immune cells and reprogramming them in a lab to identify and target […]

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