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Health

A Different Type of Dementia Is Changing What’s Known About Cognitive Decline

By Eric December 6, 2025

In a poignant revelation that highlights the complexities of dementia diagnoses, Ray Hester, a patient initially believed to be in the early stages of Alzheimer’s disease, received a surprising diagnosis after undergoing a brain scan. The scan revealed that he was actually suffering from LATE (Limbic-predominant Age-related TDP-43 Encephalopathy) dementia, a less common form of dementia that is often misdiagnosed as Alzheimer’s. This discovery brought a sense of relief to Hester and his wife, Sandy, who expressed gratitude for clarity in their situation. “There’s a certain amount of relief knowing that it’s not Alzheimer’s,” Sandy noted, emphasizing the emotional weight that such a diagnosis can carry for both patients and their families.

LATE dementia is characterized by the accumulation of TDP-43 protein in the brain, which can lead to memory loss and cognitive decline similar to Alzheimer’s but often affects different areas of the brain. This diagnosis is particularly significant as it opens up new avenues for understanding the patient’s condition and potential treatment options. For many families, receiving a precise diagnosis can be a pivotal moment, allowing them to tailor their care strategies and seek appropriate resources. The Hesters’ experience underscores the importance of thorough diagnostic processes in dementia cases, as misdiagnoses can lead to inadequate care and support. As awareness of LATE dementia grows, it is crucial for healthcare providers to consider a range of possibilities when evaluating cognitive decline, ensuring that patients receive the most accurate information and care available.

https://www.youtube.com/watch?v=IEy_xTPygN8

Doctors told Ray Hester he was in the beginning stages of Alzheimer’s, but a brain scan revealed instead he had LATE dementia. “There’s a certain amount of relief knowing that it’s not Alzheimer’s,” his wife, Sandy, said.

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