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Our guide to remaining Week 13 NFL games: Matchup previews, predictions, picks and nuggets

By Eric November 29, 2025

As Week 13 of the NFL season approaches, fans are gearing up for an exciting slate of matchups, including the Cleveland Browns hosting the San Francisco 49ers and Sam Darnold facing off against his former team, the Minnesota Vikings. This week promises to be pivotal for teams vying for playoff positions, with several games having significant implications for both wild card and division races. The Browns, currently in contention for a playoff spot, will look to capitalize on their home-field advantage against the formidable 49ers, who have been a dominant force in the NFC. With key players like quarterback Deshaun Watson leading the Browns’ offense, the matchup is set to be a thrilling clash of styles, as the Browns’ defense, known for its tenacity, aims to contain the explosive playmakers of San Francisco.

Meanwhile, Sam Darnold’s return to face the Vikings adds an intriguing narrative to the week. After a tumultuous tenure with Minnesota, Darnold has found new life with his current team, showcasing his growth and resilience. The Vikings, who have struggled with consistency this season, will be looking to exploit any weaknesses in Darnold’s game while also trying to bolster their own playoff hopes. This matchup presents a fascinating juxtaposition of Darnold’s development as a quarterback against the backdrop of his previous struggles in Minnesota. Fans can expect a tightly contested game as both teams fight for crucial wins in the lead-up to the playoffs.

As we delve into predictions and statistics for each game this week, the focus will be on key players, team strategies, and historical performance to provide insights into what fans can expect. With playoff implications on the line, Week 13 is shaping up to be a defining moment in the NFL season, filled with drama and excitement that could set the tone for the remainder of the year. Whether it’s the Browns looking to solidify their standing in the AFC or Darnold aiming to prove his worth against his former team, the stakes couldn’t be higher. Fans will want to keep an eye on these matchups as they unfold, as they could have lasting impacts on the playoff picture.

The Browns and Shedeur Sanders hosting the Niners? Sam Darnold playing his old Vikings team? We have picks, predictions and stats for every Week 13 game.

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