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National patient safety alert – harm from incorrect recording of penicillin allergy as penicillamine allergy

By Eric November 27, 2025

In a significant move to enhance patient safety, NHS England’s National Patient Safety team has issued a joint alert in collaboration with key medical organizations, including the Royal Pharmaceutical Society, the Royal College of Physicians, and the Royal College of General Practitioners. This alert focuses on a critical issue: the inadvertent mislabeling of patients’ penicillin allergies as penicillamine allergies within electronic prescribing and medicines administration (EPMA) systems. The potential for harm arises from the confusion between these two distinct substances, which can lead to inappropriate treatment decisions and increased risks for patients with genuine penicillin allergies.

Penicillin and penicillamine, while similar in name, serve very different purposes in medical treatment. Penicillin is a widely used antibiotic effective in treating various bacterial infections, while penicillamine is a medication primarily used in treating conditions such as rheumatoid arthritis and Wilson’s disease. The alert emphasizes that patients with a documented penicillin allergy may not necessarily have the same allergy to penicillamine, and misrecording these allergies could result in the avoidance of essential antibiotics for those who do not have a true penicillin allergy. This miscommunication can lead to adverse health outcomes, including prolonged infections or complications due to the lack of appropriate antibiotic therapy.

The alert calls for immediate action from healthcare professionals to ensure accurate recording of patient allergies in EPMA systems. It highlights the importance of clear communication and verification processes when documenting patient histories, particularly regarding allergies. Healthcare providers are urged to educate themselves and their teams about the distinctions between these allergies and to implement robust checks within their electronic systems to prevent such errors. By addressing this critical safety issue, the NHS aims to safeguard patient health and improve the overall quality of care in the healthcare system. The alert serves as a reminder of the ongoing need for vigilance in patient safety practices and the importance of accurate medical records in preventing harm.

A joint National Patient Safety Alert has been issued by the NHS England National Patient Safety team, in collaboration with the Royal Pharmaceutical Society, Royal College of Physicians and Royal College of General Practitioners, about the risk of harm from inadvertently recording patients’ penicillin allergies as penicillamine allergies in electronic prescribing and medicines administration (EPMA) […]

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