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US Tech & AI

Here are the 49 US AI startups that have raised $100M or more in 2025

By Eric November 27, 2025

The year 2022 marked a pivotal moment for the artificial intelligence (AI) industry, witnessing unprecedented advancements and widespread adoption across various sectors in the United States and globally. Major tech companies, startups, and research institutions accelerated their efforts in AI development, leading to breakthroughs in machine learning, natural language processing, and robotics. Notable examples include the release of advanced language models and generative AI systems, which have transformed industries such as healthcare, finance, and entertainment. Companies like OpenAI, Google, and Microsoft invested heavily in AI research, resulting in tools that can generate human-like text, analyze vast data sets, and even create art, pushing the boundaries of what machines can achieve.

As we look ahead to 2025, the AI landscape is poised for further evolution. Experts predict that the next few years will see a continued integration of AI technologies into everyday life, with applications becoming more sophisticated and accessible. For instance, the healthcare sector is expected to leverage AI for predictive analytics, personalized medicine, and improved patient outcomes. Additionally, ethical considerations surrounding AI, such as bias, privacy, and job displacement, will likely spur regulatory frameworks aimed at ensuring responsible use of technology. The demand for AI talent is anticipated to surge, prompting educational institutions to adapt their curricula to prepare the workforce for an AI-driven economy. Overall, while 2022 set the stage for AI innovation, the years leading up to 2025 are expected to refine and expand the impact of AI, making it an integral part of our daily lives and the global economy.

Last year was monumental for the AI industry in the U.S. and beyond. How will 2025 compare?

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