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National patient safety alert – harm from incorrect recording of penicillin allergy as penicillamine allergy

By Eric November 23, 2025

In a significant move to enhance patient safety, NHS England’s National Patient Safety team, in collaboration with esteemed organizations such as the Royal Pharmaceutical Society, the Royal College of Physicians, and the Royal College of General Practitioners, has issued a joint National Patient Safety Alert. This alert addresses a critical issue in electronic prescribing and medicines administration (EPMA) systems: the inadvertent recording of patients’ penicillin allergies as penicillamine allergies. This mix-up poses a serious risk of harm to patients, potentially leading to inappropriate medication prescriptions and adverse drug reactions.

Penicillin and penicillamine are distinct substances, with penicillin being a widely used antibiotic and penicillamine serving primarily as a treatment for conditions like rheumatoid arthritis and Wilson’s disease. The alert emphasizes the importance of accurate allergy documentation, as mislabeling can lead to significant clinical consequences. For instance, if a patient is mistakenly recorded as allergic to penicillamine when they are actually allergic to penicillin, healthcare providers may avoid prescribing essential medications, thereby compromising the patient’s treatment plan. The alert encourages healthcare professionals to double-check allergy entries in EPMA systems and to ensure that patients’ allergy histories are thoroughly reviewed during consultations.

The National Patient Safety Alert serves as a crucial reminder of the potential pitfalls in electronic health records and the importance of vigilance in patient care. It highlights the necessity for healthcare providers to engage in clear communication with patients about their allergies and to take the time to verify recorded information. By adhering to the guidelines outlined in the alert, healthcare professionals can significantly reduce the risk of medication errors and enhance overall patient safety. This initiative reflects a broader commitment within the NHS to improve healthcare quality through better data management and patient-centered practices.

A joint National Patient Safety Alert has been issued by the NHS England National Patient Safety team, in collaboration with the Royal Pharmaceutical Society, Royal College of Physicians and Royal College of General Practitioners, about the risk of harm from inadvertently recording patients’ penicillin allergies as penicillamine allergies in electronic prescribing and medicines administration (EPMA) […]

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